PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES

PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES

The present invention relates to the use of certain 4-substituted pyrimidine derivatives as mGluR1 antagonists, to novel 4-substituted pyrimidine derivatives, to pharmaceutical formulations comprising 4-substituted pyrimidine derivatives, to a process for preparing 4-substituted pyrimidine derivativ...

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Bibliographische Detailangaben
Hauptverfasser: COLEMAN, DARRELL, STEPHEN, HONG, JIAN, ERIC, AMBLER, SAMANTHA, JAYNE, GOLDSWORTHY, JOHN, SCHOEPP, DARRYLE, DARWIN, BAKER, STEPHEN, RICHARD, JOHNSON, KIRK, WILLIS, CLARK, BARRY, PETER, SCHKERYANTZ, JEFFREY, MICHAEL, KINGSTON, ANN, ELIZABETH, VANNIEUWENHZE, MICHAEL, SCOTT, OWTON, WILLIAM, MARTIN, ZIA-EBRAHIMI, MOHAMMAD, SADEGH, JAGDMANN, GUNNAR, ERIK, JUNIOR, FOGLESONG, ROBERT, JAMES
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to the use of certain 4-substituted pyrimidine derivatives as mGluR1 antagonists, to novel 4-substituted pyrimidine derivatives, to pharmaceutical formulations comprising 4-substituted pyrimidine derivatives, to a process for preparing 4-substituted pyrimidine derivatives and to intermediates useful in the preparation of 4-substituted pyrimidine derivatives. L'invention concerne l'utilisation de certains dérivés de pyrimidine 4-substituée en tant qu'antagonistes de mGluR1, de nouveaux dérivés de pyrimidine 4-substituée, des formulations pharmaceutiques contenant des dérivés de pyrimidine 4-substituée, un procédé de préparation de dérivés de pyrimidine 4-substituée et des intermédiaires utiles dans la préparation de dérivés de pyrimidine 4-substituée.