DRUG DISCHARGE PUMP INHIBITORS

Drugs for preventing and/or treating microbial infectious diseases which contain, as the active ingredient, compounds represented by the formula (I), physiologically acceptable salts thereof or hydrates of the same and have an effect of making a microorganism having acquired tolerance to a drug non-...

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Bibliographische Detailangaben
Hauptverfasser:	NAKAYAMA, KIYOSHI, RENAU, THOMAS, ERIC, KAWATO, HARUKO, WATKINS, WILLIAM, JOHN, OHTA, TOSHIHARU, LEGER, ROGER, LEE, VING, JACK, ISHIDA, YOHHEI, OHTSUKA, MASAMI, ZHANG, JASON, ZHIJIA
Format:	Patent
Sprache:	eng ; fre ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Drugs for preventing and/or treating microbial infectious diseases which contain, as the active ingredient, compounds represented by the formula (I), physiologically acceptable salts thereof or hydrates of the same and have an effect of making a microorganism having acquired tolerance to a drug non-tolerant. In said formula R and R independently represent each hydrogen, halogeno, carboxy, etc.; J represents 5- or 6-membered heteroaryl; W represents -CH=CH-, -CHCH-, -CH2CH2-, etc.; A represents phenylene, pyridinedyl, furandyl, etc.; G represents oxygen, carbonyl, ethynyl, etc.; p is an integer of from 0 to 3; G represents phenylene, furandyl, tetrahydrofurandyl, etc.; G represents -CH2- or a single bond; m and n represent each an integer of 0 or 1; and Q represents an acidic group. L'invention concerne des médicaments pour la prévention et/ou le traitement d'infections microbiennes, qui renferment comme principe actif des composés représentés par la formule générale (I), y compris leurs sels physiologiquement acceptables ou hydrates, et qui rendent non tolérant un micro-organisme ayant une tolérance acquise. Dans ladite formule, R et R sont indépendamment chacun hydrogène, halogéno, carboxy, etc.; J est hétéroaryle à 5 ou 6 éléments; W est -CH=CH-, -CHCH-, etc.; A est phénylène, pyridinedyle, furandyle, etc.; G est oxygène, carbonyle, éthynyle, etc.; p est un entier valant de 0 à 3; G est phénylène, furandyle, tétrahydrofurandyle, etc.; G est -CH2- ou une liaison unique; m et n sont chacun un entier valant de 0 à 1; et Q est un groupe acide.