METHOD FOR THE SELECTIVE PROTECTION OF PROLIFERATING NORMAL CELLS AND THE SELECTIVE ERADICATION OF TUMOR CELLS HAVING AN INACTIVE p53 PATHWAY

Object of the present invention is a method for obtaining the selective protection of normal cells and, at the same time, the selective eradication of tumor cells having an inactive p53 pathway. Further objects of the present invention are the uses of the compounds of the method, pharmaceutical comp...

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Bibliographische Detailangaben
Hauptverfasser:	ZANETTI, ANTONIO, TATO', FRANCO, GROSSI, MILENA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Object of the present invention is a method for obtaining the selective protection of normal cells and, at the same time, the selective eradication of tumor cells having an inactive p53 pathway. Further objects of the present invention are the uses of the compounds of the method, pharmaceutical compositions and kits, comprising such compounds as active principles, and use of the C3H10T1/2 cells for implementing methods for the eradication of tumor cells having an inactive p53 pathway. L'invention porte sur une méthode permettant de protéger de manière sélective les cellules normales et, en même temps, d'éradiquer de manière sélective les cellules tumorales ayant une voie p53 inactive. La présente invention concerne également les utilisations des composés de cette méthode, des compositions pharmaceutiques et des kits comprenant de tels composés en tant qu'agents actifs, et l'utilisation des cellules C3H10T1/2 dans la mise en oeuvre de méthodes d'éradication de cellules tumorales ayant une voie p53 inactive.