RXR MODULATORS WITH IMPROVED PHARMACOLOGIC PROFILE

The present invention provides a novel class of RXR modulator compounds that exhibit an improved pharmacologic profile relative to the profile of previously studied RXR modulators, including those that share common structural features with the presently claimed modulators. The present invention also...

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Bibliographische Detailangaben
Hauptverfasser:	JONES, TODD, K, THOMPSON, ANTHONY, J, FAULKNER, AMY, L, CHEN, JYUN-HUNG, BOEHM, MARCUS, F, HAMANN, LAWRENCE, G, MAPES, CHRISTOPHER, M, MICHELLYS, PIERRE-YVES, TYHONAS, JOHN, S, ARDECKY, ROBERT, J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a novel class of RXR modulator compounds that exhibit an improved pharmacologic profile relative to the profile of previously studied RXR modulators, including those that share common structural features with the presently claimed modulators. The present invention also provides synthetic methods for preparing these compounds as well as pharmaceutical compositions incorporating these novel compounds and methods for the therapeutic use of such compounds and pharmaceutical compositions. La présente invention concerne une nouvelle catégorie de composés de modulateurs RXR présentant un profil pharmacologique amélioré par rapport à celui des modulateurs RXR étudiés antérieurement, y compris les modulateurs partageant des caractéristiques structurales communes avec les modulateurs de la présente invention. Cette dernière concerne également des procédés de synthèse permettant de préparer ces composés et des compositions pharmaceutiques contenant ces nouveaux composés, ainsi que des méthodes destinées à l'utilisation thérapeutique de ces composés et de ces compositions pharmaceutiques.