GLUCURONOXYLOMANNAN (GXM)-O-ACETYLHYDROLASE OF CRYPTOCOCCUS NEOFORMANS AND USES THEREOF

The present invention provides a novel enzyme which de-O-acetylates glucuronoxylomannan of Cryptococcus neoformans and a gene encoding such enzyme. Also provided are applications of such enzyme in treating cryptococcosis. La présente invention concerne, d'une part une nouvelle enzyme qui dés-O-...

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Bibliographische Detailangaben
Hauptverfasser:	SAVOY, ANNE, C, KOZEL, THOMAS, R, BLOOMER, SHERRI, L
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a novel enzyme which de-O-acetylates glucuronoxylomannan of Cryptococcus neoformans and a gene encoding such enzyme. Also provided are applications of such enzyme in treating cryptococcosis. La présente invention concerne, d'une part une nouvelle enzyme qui dés-O-acétylise le glucuronoxylomannane de Cryptococcus neoformans et d'autre part un gène codant une telle enzyme. L'invention concerne également des applications d'une telle enzyme pour le traitement de la cryptococcose.