DRUG RELEASING BIODEGRADABLE FIBER IMPLANT

The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal dis...

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Bibliographische Detailangaben
Hauptverfasser:	ROMERO-SANCHEZ, ANDRES, A., A, RADULESCU, DELIA, WAGGONER, PAULA, SMITH, GEORGE, M, ALIKACEM, NADIR, HU, ZHIBING, NELSON, KEVIN, D
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBONFILAMENTS CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS,THREADS, FIBRES, BRISTLES OR RIBBONS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR HUMAN NECESSITIES HYGIENE LAUNDERING MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL NATURAL OR ARTIFICIAL THREADS OR FIBRES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPINNING TEXTILES TREATMENT OF TEXTILES OR THE LIKE TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS,FABRICS, FEATHERS, OR FIBROUS GOODS MADE FROM SUCH MATERIALS
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Beschreibung
Zusammenfassung:	The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices. L'invention concerne des compositions de génie tissulaire et des procédés associés. Des matrices tridimensionnelles pour cultiver des cellules sont préparées pour utilisation in vitro et in vivo. Ces matrices comportent des fibres polymères biodégradables capables de libérer des agents thérapeutiques. La distribution spatiale et temporelle des agents thérapeutiques libérés est régulée par l'emploi de motifs non homogènes d'agents thérapeutiques dans les matrices.