STREPTAVIDIN EXPRESSED GENE FUSIONS AND METHODS OF USE THEREOF

The present invention provides vectors for expressing genomic streptavidin fusion cassettes. In the various embodiments, fusion proteins produced from these vectors are provided. In particular embodiments, fusion proteins comprising a single chain antibody and genomic streptavidin are provided as ar...

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Bibliographische Detailangaben
Hauptverfasser:	SANDERSON, JAMES, ALLEN, LIN, YUKANG, RENO, JOHN, M, SCHULTZ, JOANNE, ELAINE, GOSHORN, STEPHEN, CHARLES, GRAVES, SCOTT, STOLL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides vectors for expressing genomic streptavidin fusion cassettes. In the various embodiments, fusion proteins produced from these vectors are provided. In particular embodiments, fusion proteins comprising a single chain antibody and genomic streptavidin are provided as are vectors encoding the same. Also provided, are methods of using the fusion proteins of the present invention, and in particular, the use of scFvSA fusion proteins as diagnostic markers or as a cell specific targeting agents. La présente invention concerne des vecteurs servant à exprimer des cassettes de fusion issues de la streptavidine génomique. Divers modes de réalisation de l'invention décrivent des protéines de fusion obtenues à partir de ces vecteurs. Des modes de réalisation particuliers décrivent des protéines de fusion comprenant un anticorps à chaîne unique et la streptavidine génomique, ainsi que des vecteurs codant lesdites protéines. L'invention concerne en outre des méthodes d'utilisation des protéines de fusion de l'invention et, notamment, l'utilisation de protéines de fusion scFvSA comme marqueurs de diagnostic ou comme agents de ciblage spécifiques à une cellule.