A NEMATODE DRUG SCREEN FOR MODULATORS OF MAMMALIAN DISORDERS

The invention provides rapid, versatile, and economic assay methods to screen for modulators of egg laying behavior in nematodes, by determining the activity of chitinase in the culture medium, thereby screening for candidate compounds that modulate a trait characteristic of mammalian disorders or d...

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Bibliographische Detailangaben
Hauptverfasser:	GURNEY, MARK, E, THOMAS, EILEEN, M, GEARY, TIMOTHY, G, ELLERBROCK, BRENDA, R
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides rapid, versatile, and economic assay methods to screen for modulators of egg laying behavior in nematodes, by determining the activity of chitinase in the culture medium, thereby screening for candidate compounds that modulate a trait characteristic of mammalian disorders or diseases such as Alzheimer's disease, Ras-inducible cancer, and cardiopulmonary disease characterized by aberrant potassium channel function, among others. Also provided are modulators identified using the methods of the invention, pharmaceutical compositions including the modulators, and methods of using the modulators or pharmaceutical compositions to modulate a mammalian disorder or disease. L'invention porte sur des procédés rapides, polyvalents et économiques d'essais servant au criblage des modulateurs de la conduite de ponte des nématodes pouvant par là cribler les composés candidats modulant un trait caractéristique de troubles apparaissant chez les mammifères ou de maladies telles que la maladie d'Alzheimer, le cancer induit par le Ras, les maladies cardio-pulmonaires caractérisés notamment par un fonctionnement aberrant des canaux potassiques. L'invention porte également sur les modulateurs identifiés à l'aide des susdits procédés, sur des préparations pharmaceutiques les contenant, et sur des procédés d'utilisation de ces modulateurs et compositions pharmaceutiques pour moduler des troubles et maladies apparaissant chez les mammifères.