METHOD FOR SEQUENCY AND CHARACTERIZING POLYMERIC BIOMOLECULES USING APTAMERS AND A METHOD FOR PRODUCING APTAMERS

METHOD FOR SEQUENCY AND CHARACTERIZING POLYMERIC BIOMOLECULES USING APTAMERS AND A METHOD FOR PRODUCING APTAMERS

The present invention relates to methods for sequencing a polymeric biomolecule and methods for structurally characterizing the same comprising using aptamers. In a preferred embodiment of this invention, these methods relate to using the single polymeric biomolecule. The invention also relates to a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MITSIS, PAUL, G, KWAGH, JAE-GYU, MACKLIN, JOHN, J, ULMER, KEVIN, M
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention relates to methods for sequencing a polymeric biomolecule and methods for structurally characterizing the same comprising using aptamers. In a preferred embodiment of this invention, these methods relate to using the single polymeric biomolecule. The invention also relates to a method for selecting aptamers useful for sequencing nucleic acids and aptamers generated by the method. The invention also provides aptamers that recognize and bind to AMP, dAMP, GMP, dGMP, CMP and dCMP. L'invention concerne des procédés de séquençage d'une biomolécule polymère et des procédés de sa caractérisation structurelle au moyen d'aptamères. Dans un mode de réalisation préféré de l'invention, ces procédés consistent à utiliser la biomolécule polymère unique. L'invention concerne aussi un procédé pour sélectionner les aptamères utiles pour le séquençage d'acides nucléiques et des aptamères générés par ce procédé. L'invention concerne enfin des aptamères qui reconnaissent AMP, dAMP, GMP, dGMP, CMP et dCMP et qui s'y lient.