DRUG TARGETS IN CANDIDA ALBICANS

The present invention is concerned with the identification of genes or functional fragments thereof from Candida albicans which are critical for growth and cell division and which genes may be used as selective drug targets to treat Candida albicans associated infections. Novel nucleic acid sequence...

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Bibliographische Detailangaben
Hauptverfasser:	VIAENE, JASMINE, ELZA, VIALARD, JORGE, EDWARDS, LOGGHE, MARC, GEORGE, LUYTEN, WALTER, HERMAN, MARIA, LOUIS, DE BACKER, MARIANNE, DENISE, NELISSEN, BART, CONTRERAS, ROLAND, HENRI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is concerned with the identification of genes or functional fragments thereof from Candida albicans which are critical for growth and cell division and which genes may be used as selective drug targets to treat Candida albicans associated infections. Novel nucleic acid sequences from Candida albicans are also provided and which encode the polypeptides which are critical for growth of Candida albicans. Methods for the identification of anti-fungal compounds which inhibit fungal or yeast growth are also contemplated. La présente invention concerne l'identification de gènes provenant de Candida albicans, ou de leurs fragments fonctionnels, indispensables au développement et à la division cellulaire, ces gènes pouvant être utilisés comme cibles médicamenteuses sélectives pour traiter les infections associées aux Candida albicans. En outre, cette invention concerne de nouvelles séquences d'acides nucléiques provenant de Candida albicans codant les polypeptides indispensables à la croissance des Candida albicans. De plus, cette invention concerne des procédés d'identification de composés antifongiques qui inhibent le développement des champignons ou des levures.