BENZYLMALTOTRIOSIDES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION

This invention provides smooth muscle cell proliferation inhibitors of formula (I) having the structure wherein X is (A) wherein R , R , R , R , R , R , R , R , R and R , are each, independently, hydrogen, acyl of 2-7 carbon atoms, perfluoroacyl of 2-10 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, benzoyl, benzyl or -SO3M; M is hydrogen, lithium, sodium, potassium or ammonium; R is hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atomes, halogen, nitrile, nitro, or alkoxy of 1-6 carbon atoms; R is hydrogen, nitro, amino, acylamino of 2-7 carbon atoms, perfluoroacylamino of 2-7 carbon atoms, alkylamino of 1-6 carbon atoms, perfluoroalkylamino of 1-6 carbon atoms, dialklylamino where each alkyl chain is independently 1-6 carbon atoms, perfluorodialklylamino where each alkyl chain is independently 1-6 carbon atoms, alkylsulfonylamino of 1-6 carbon atoms, perfluoroalkyl-sulfonylamino of 1-6 carbon atoms, arylsulfonylamino of 6-10 carbon atoms or arylsulfonylamino substituted with halo of 6-10 carbon atoms; or a pharmaceutically acceptable salt thereof. La présente invention concerne des inhibiteurs de la prolifération des cellules des muscles lisses représentés par la formule générale (I), ou certains de leurs sels pharmaceutiquement admis. Dans cette formule générale (I), X est tel que représenté par la formule (A). R , R , R , R , R , R , R , R , R et R sont chacun indépendamment C2-C7 acyle, C2-C10 perfluoroacyle, C1-C6 alkyle, C1-C6 perfluoroalkyle, benzoyle, benzyle ou -SO3M; M est hydrogène, lithium, sodium, potassium ou ammonium; R est hydrogène, C1-C6 alkyle; R est hydrogène, nitro, amino, C2-C7 acylamino, C2-C7 perfluoroacylamino, C1-C6 alkylamino, C1-C6 perfluoroalkylamino, dialklylamino où chaque chaîne alkyle est indépendamment C1-C6 alkyle, perfluorodialklylamino où chaque chaîne alkyle est indépendamment C1-C6 alkyle, C1-C6 alkylsulfonylamino, C1-C6 perfluoroalkylsulfonylamino, C1-C6 arylsulfonylamino ou arylsulfonylamino substitué par C6-C10 halo.