BIOLOGICAL ASSAY COMPOSITIONS CONTAINING NON-INTERFERING, FOAM-INHIBITING AND FOAM-COLLAPSING AGENTS

There are provided compositions, manufactures and methods for performing biological assays, particularly immunoassays in which the generation and persistence of foam, that can interfere with the assay, is inhibited. Such compositions include, for example silicone-based anti-foaming agents, silicone-...

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Bibliographische Detailangaben
Hauptverfasser: GARRITY, MARTHA, LOUISE, DIAMOND, RONALD, N
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:There are provided compositions, manufactures and methods for performing biological assays, particularly immunoassays in which the generation and persistence of foam, that can interfere with the assay, is inhibited. Such compositions include, for example silicone-based anti-foaming agents, silicone-glycol emulsions, and polyalkylsiloxane. In a preferred method, the compositions and/or manufactures are used in conjunction with an automated biological assay apparatus which includes a pipetting means which is equipped with a clot detection means. L'invention concerne des compositions, des produits manufacturés et des techniques qui facilitent la mise en oeuvre des analyses biologiques, notamment des dosages immunologiques, en inhibant la formation et la persistance de mousse susceptible de perturber ladite analyse. Ces compositions renferment par exemple des agents antimousse à base de silicone, des émulsions silicone-glycol et du polyalkylsiloxane. Selon la technique préférée, ces compositions et/ou produits sont utilisés en association avec un automate d'analyse biologique qui comporte un système de pipettage pourvu d'un système de détection des caillots.