EXON DELETION ANTISENSE DRUG DESIGN AND THERAPY

The present invention provides a method for designing antisense oligodeoxynucleotides (ODNs) and long antisense expression vectors which produce long antisense RNA sequences for inhibiting the translation of specific isoforms, or families of isoforms, of a protein. The invention also provides method...

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Bibliographische Detailangaben
Hauptverfasser:	BROADDUS, WILLIAM, C, GILLIES, GEORGE, T, FILLMORE, HELEN, CONRAD, WILLIAM, S
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a method for designing antisense oligodeoxynucleotides (ODNs) and long antisense expression vectors which produce long antisense RNA sequences for inhibiting the translation of specific isoforms, or families of isoforms, of a protein. The invention also provides methods of use for the ODNs and long antisense expression vectors which produce long antisense RNA sequences. L'invention concerne un procédé de conception d'oligodésoxynucléotides (ODN) antisens et de vecteurs longs d'expression antisens, lesquels produisent des séquences longues d'ARN antisens, destinées à inhiber la traduction d'isoformes spécifiques, ou de familles d'isoformes, d'une protéine. L'invention concerne également des méthodes d'utilisation de ces ODN et des vecteurs longs d'expression antisens, lesquels produisent des séquences longues d'ARN antisens.