PROCESS FOR MAKING FARNESYL-PROTEIN TRANSFERASE INHIBITORS

PROCESS FOR MAKING FARNESYL-PROTEIN TRANSFERASE INHIBITORS

The present invention is directed to the improved synthesis of compounds of formula (I): which may be useful as farnesyl-protein transferase inhibitors. The present invention is also directed to the crystal forms of the monohydrate and mon-hydrochloride salt of 1-(3-Chlorophenyl)-4-[1-(4-cyanobenzyl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MCCAULEY, JAMES, A, COWEN, JENNIFER, A, ASKIN, DAVID, MALIGRES, PETER, E, MCWILLIAMS, J., CHRISTOPHER
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention is directed to the improved synthesis of compounds of formula (I): which may be useful as farnesyl-protein transferase inhibitors. The present invention is also directed to the crystal forms of the monohydrate and mon-hydrochloride salt of 1-(3-Chlorophenyl)-4-[1-(4-cyanobenzyl)-5-imidazolylmethyl]-2-piperazinone. La présente invention concerne la synthèse améliorée de composés de la formule (I) qui peuvent être utiles comme inhibiteurs de farnésyl-protéine transférase. La présente invention concerne également les formes cristallines du sel de monohydrate et de monochlorhydrate de 1-(3-Chlorophényl)-4-[1-(4-cyanobenzyl)-5-imidazolylméthyl]-2-pipérazinone.