DERIVADOS DE PIRROLOPIRIDINA SUSTITUIDOS

La invención se refiere a derivados de pirrolopiridina sustituidos por inhibidores de proteína de la fórmula (I) a composiciones farmacéuticas y combinaciones que comprenden dichos compuestos, y a su uso profiláctico y terapéutico en trastornos neoplásicos, respectivamente cáncer o afecciones con respuestas inmunológicas desreguladas u otros trastornos asociados con la señalización de MAP4K1 aberrante, como único agente o en combinación con otros ingredientes activos, tales como hiperplasias benignas, trastornos ateroscleróticos, sepsis, trastornos autoinmunes, trastornos vasculares, infecciones virales, en trastornos neurodegenerativos, en trastornos inflamatorios, en trastornos ateroscleróticos y en el control de fertilidad masculina. The present invention relates to protein-inhibitory substituted pyrrolopyridine derivatives of formula (I), in which A, X, R1, R2a, R2b, R3a, R3b, R4a and R4b are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, repectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients. The present invention further relates to the use, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control.