Display screen with animated user interface

A plurality of columns each having a plurality of symbol positions are displayed. A gaming system generates and displays one of a plurality of symbols in each symbol position. At least one of the plurality of symbols is a designated symbol with an indicated quantity. The indicated quantity indicates whether the designated symbol is active or inactive. For each winning symbol combination containing at least one designated symbol, the indicated quantity associated with any designated symbol in the winning symbol combination is decremented and any non-designated symbols are removed from the display. Any designated symbols with an associated numeral of zero are inactive and are removed from each winning symbol combination. Any remaining symbols are shifted in a predetermined direction. For each empty symbol position, the gaming system generates and displays a new symbol and repeats the above steps until no winning symbol combinations remain.