Geminally substituted cyanoethylpyrazolo pyridones as Janus kinase inhibitors

Geminally substituted cyanoethylpyrazolo pyridones as Janus kinase inhibitors

The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

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Bibliographische Detailangaben
Hauptverfasser: Falcone, Danielle, Zeng, Hongbo, Martinez, Michelle, Kong, Norman, Thompson, Christopher F, Kurukulasuriya, Ravi, Deng, Yongqi, Bai, Yunfeng, Liu, Yumei, Zheng, Zhixiang, Katz, Jason David, Torres, Luis, Fuller, Peter, Guerin, David, Pu, Qinglin, Childers, Matthew Lloyd, Scott, Mark E
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.