Azaquinazoline inhibitors of atypical protein kinase C

The present application provides azaquinazoline compounds as defined herein. This application further describes compositions comprising the same. These azaquinazoline compounds and their salts have atypical protein kinase C ("aPKC") inhibitory activity, and may be used to treat proliferati...

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Bibliographische Detailangaben
Hauptverfasser:	Ott Gregory R, Morris Emma L, Breslin Henry J, Zulli Allison L, Olowoye Ikeoluwa, Dugan Benjamin J, Zificsak Craig A, Pave Gregoire A, Monck Nathaniel J. T, Tao Ming, Roffey Jonathan R. A, Fowler Katherine M, Mesaros Eugen F, Soudy Christelle N, Dorsey Bruce D, Hudkins Robert L
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present application provides azaquinazoline compounds as defined herein. This application further describes compositions comprising the same. These azaquinazoline compounds and their salts have atypical protein kinase C ("aPKC") inhibitory activity, and may be used to treat proliferative disorders.