Cross clock compensation between layers in peripheral component interconnect express

A PCIe bus adapted for cross clock compensation of asynchronous clocks includes one or more PHY data ports provided in a PHY layer having a transmit clock (TCLK) for timing data transmitted to a peripheral device and a receive clock (RCLK) for timing data received from the peripheral device, one or more media access control (MAC) ports provided in a MAC layer having an interface clock (PCLK) for timing data transmitted to the PHY layer and data received from the PHY layer, wherein the PCLK and one or both of the TCLK and the RCLK are asynchronous, and one or more backpressure ports at an interface between the PHY layer and the MAC layer for controlling reading and writing of one of the PHY layer and the MAC layer. In some aspects, the PCLK frequency is set to be always greater than a maximum frequency of the RCLK and the TCLK.