Polyurethane having an antithrombogenic coating

The invention concerns polyurethane (PUR) having an antithrombogenic coating, wherein the antithrombogenic coating comprises at least one antithrombogenic substance covalently bound to a surface of the PUR via at least two bonds, wherein a first of said bonds is an amide bond between the surface of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Schmid Christof, Lukas Karin, Zimmermann Hanngörg, Schmid Thomas, Stadtherr Karin, Wehner Daniel, Lehle Karla
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention concerns polyurethane (PUR) having an antithrombogenic coating, wherein the antithrombogenic coating comprises at least one antithrombogenic substance covalently bound to a surface of the PUR via at least two bonds, wherein a first of said bonds is an amide bond between the surface of the PUR and a polyethyleneimine (PEI) and a second of said bonds is between the PEI and the antithrombogenic substance, wherein the surface of the PUR had been activated by use of a carbon dioxide plasma or a plasma modified by addition of carbon dioxide before the first of said bonds was formed.