Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents

Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents

Alternative continuous downstream processes for the production of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide ("Compound A") are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially avail...

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Bibliographische Detailangaben
Hauptverfasser: Haaland Torfinn, Farbrot Alf Martin, Saanum Inger Dagny, Askildsen Arne, Kalleberg Rita Heskestad, Silalahi Sumihar
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Alternative continuous downstream processes for the production of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide ("Compound A") are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially available non-ionic x-ray contrast media agents.