Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors

Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors

The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Otte Ryan D, Ellis John Michael, Andresen Brian M, Robichaud Joel S, Arrington Kenneth L, Northrup Alan B, Gauthier Jacques Yves, Fournier Jean-Francois, Butcher John W
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).