Method for producing 4-borono-L-phenylalanine having 18F atom introduced thereinto, and precursor of 4-borono-L-phenylalanine having 18F atom introduced thereinto

Method for producing 4-borono-L-phenylalanine having 18F atom introduced thereinto, and precursor of 4-borono-L-phenylalanine having 18F atom introduced thereinto

The purpose of the present invention is to provide: a novel method for producing 18 F-labeled 4-boronophenylalanine (BPA) ; and a precursor of 18 F-labeled BPA. 18 F-labeled BPA can be produced by preparing a compound represented by formula (1) and using the compound. In the formula, R1 represents a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Takenaka Hiroshi, Taguchi Yusuke, Uehara Kohki, Kirihata Mitsunori, Ueda Sayuri, Ishino Yuko, Yoshikawa Tomohiro, Nakashima Hideki, Ohta Yoichiro
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The purpose of the present invention is to provide: a novel method for producing 18 F-labeled 4-boronophenylalanine (BPA) ; and a precursor of 18 F-labeled BPA. 18 F-labeled BPA can be produced by preparing a compound represented by formula (1) and using the compound. In the formula, R1 represents a bromo group, an iodo group, a fluoro group, a diazaborinane derivative, BX3- or BX3-M+ (wherein X represents a halogen atom; and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation).