Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same
The present invention relates to an antibody-linker-drug conjugate in which an antibody and a cytotoxic drug are conjugated through an enzyme cleavable peptide linker capable of directly binding to a lysine residue of an antibody, a preparation method therefor, and an anticancer drug composition con...
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| creator | Jeong Jin-kyo Lee Jin Seo Kim Kyoung Suk Cho Eun Joo Kim Joon woo Hong Seung Suh Park Young Jun Choi Young Mi Kim Yeon Jung Lee Matthew Sangyup Lee In-Suk Lee Minseob Song Hyunnam Lee Jong-hyoup Park Sung Jun Choi Joon hun |
| description | The present invention relates to an antibody-linker-drug conjugate in which an antibody and a cytotoxic drug are conjugated through an enzyme cleavable peptide linker capable of directly binding to a lysine residue of an antibody, a preparation method therefor, and an anticancer drug composition containing the same as an active ingredient. |
| format | Patent |
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Song Hyunnam ; Lee Jong-hyoup ; Park Sung Jun ; Choi Joon hun</creator><creatorcontrib>Jeong Jin-kyo ; Lee Jin Seo ; Kim Kyoung Suk ; Cho Eun Joo ; Kim Joon woo ; Hong Seung Suh ; Park Young Jun ; Choi Young Mi ; Kim Yeon Jung ; Lee Matthew Sangyup ; Lee In-Suk ; Lee Minseob ; Song Hyunnam ; Lee Jong-hyoup ; Park Sung Jun ; Choi Joon hun</creatorcontrib><description>The present invention relates to an antibody-linker-drug conjugate in which an antibody and a cytotoxic drug are conjugated through an enzyme cleavable peptide linker capable of directly binding to a lysine residue of an antibody, a preparation method therefor, and an anticancer drug composition containing the same as an active ingredient.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171114&DB=EPODOC&CC=US&NR=9814784B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171114&DB=EPODOC&CC=US&NR=9814784B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Jeong Jin-kyo</creatorcontrib><creatorcontrib>Lee Jin Seo</creatorcontrib><creatorcontrib>Kim Kyoung Suk</creatorcontrib><creatorcontrib>Cho Eun Joo</creatorcontrib><creatorcontrib>Kim Joon woo</creatorcontrib><creatorcontrib>Hong Seung Suh</creatorcontrib><creatorcontrib>Park Young Jun</creatorcontrib><creatorcontrib>Choi Young Mi</creatorcontrib><creatorcontrib>Kim Yeon Jung</creatorcontrib><creatorcontrib>Lee Matthew Sangyup</creatorcontrib><creatorcontrib>Lee In-Suk</creatorcontrib><creatorcontrib>Lee Minseob</creatorcontrib><creatorcontrib>Song Hyunnam</creatorcontrib><creatorcontrib>Lee Jong-hyoup</creatorcontrib><creatorcontrib>Park Sung Jun</creatorcontrib><creatorcontrib>Choi Joon hun</creatorcontrib><title>Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same</title><description>The present invention relates to an antibody-linker-drug conjugate in which an antibody and a cytotoxic drug are conjugated through an enzyme cleavable peptide linker capable of directly binding to a lysine residue of an antibody, a preparation method therefor, and an anticancer drug composition containing the same as an active ingredient.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDEOwjAMRbswIOAOPkAzAJUoIyAQOzBXJnFbQ-tEiTtweyrUAzB8veW9P8-6gyg_vfuYjuVN0bg4NGC9vIYGlXIIkQJGVPYCPWnrHWhLkWofc0Bx45QtiqUIU9sHn_gXjD-KLCwNJOxpmc1q7BKtJi4yuJzvp6uh4CtKAS0JafW47ct1sSuL42b7h_IFCZJCYA</recordid><startdate>20171114</startdate><enddate>20171114</enddate><creator>Jeong Jin-kyo</creator><creator>Lee Jin Seo</creator><creator>Kim Kyoung Suk</creator><creator>Cho Eun Joo</creator><creator>Kim Joon woo</creator><creator>Hong Seung Suh</creator><creator>Park Young Jun</creator><creator>Choi Young Mi</creator><creator>Kim Yeon Jung</creator><creator>Lee Matthew Sangyup</creator><creator>Lee In-Suk</creator><creator>Lee Minseob</creator><creator>Song Hyunnam</creator><creator>Lee Jong-hyoup</creator><creator>Park Sung Jun</creator><creator>Choi Joon hun</creator><scope>EVB</scope></search><sort><creationdate>20171114</creationdate><title>Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same</title><author>Jeong Jin-kyo ; 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same |
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