Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same

Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same

The present invention relates to an antibody-linker-drug conjugate in which an antibody and a cytotoxic drug are conjugated through an enzyme cleavable peptide linker capable of directly binding to a lysine residue of an antibody, a preparation method therefor, and an anticancer drug composition con...

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Bibliographische Detailangaben
Hauptverfasser: Jeong Jin-kyo, Lee Jin Seo, Kim Kyoung Suk, Cho Eun Joo, Kim Joon woo, Hong Seung Suh, Park Young Jun, Choi Young Mi, Kim Yeon Jung, Lee Matthew Sangyup, Lee In-Suk, Lee Minseob, Song Hyunnam, Lee Jong-hyoup, Park Sung Jun, Choi Joon hun
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to an antibody-linker-drug conjugate in which an antibody and a cytotoxic drug are conjugated through an enzyme cleavable peptide linker capable of directly binding to a lysine residue of an antibody, a preparation method therefor, and an anticancer drug composition containing the same as an active ingredient.