Solid forms of Ivacaftor and processes for the preparation thereof

Solid forms of Ivacaftor and processes for the preparation thereof

Provided herein is a polymorphic form of Ivacaftor, namely APO-I, as well as processes for the preparation and pharmaceutical compositions of the same. Also, provided is a new solvate of Ivacaftor, processes for its preparation and use in the preparation of pure Ivacaftor.

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Bibliographische Detailangaben
Hauptverfasser: Vijaya Bhaskar Ekkaluru, Shreenivasa Murthy Heggadde Nanjunda Bhatta, Venkata Ramana Kintali, Akbarali Padiyath Mohammed, Manjunath Karad, Sunil Kumar Nechipadappu, Suresh Kumar Sankaran
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided herein is a polymorphic form of Ivacaftor, namely APO-I, as well as processes for the preparation and pharmaceutical compositions of the same. Also, provided is a new solvate of Ivacaftor, processes for its preparation and use in the preparation of pure Ivacaftor.