Transportation network utilizing autonomous vehicles for transporting items

A transportation network is provided that utilizes autonomous vehicles (e.g., unmanned aerial vehicles) for identifying, acquiring, and transporting items between network locations without requiring human interaction. A travel path for an item through the transportation network may include a passing of the item from one autonomous vehicle to another or otherwise utilizing different autonomous vehicles for transporting the item along different path segments (e.g., between different network locations). Different possible travel paths through the transportation network may be evaluated, and a travel path for an item may be selected based on transportation factors such as travel time, cost, safety, etc., which may include consideration of information regarding current conditions (e.g., related to network congestion, inclement weather, etc.). Autonomous vehicles of different sizes, carrying capacities, travel ranges, travel speeds, etc. may be utilized for further improving the flexibility and efficiency of the system for transporting items.