Antibody constructs for CDH19 and CD3

The present invention provides a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds a human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Blumel Claudia, Pan Zheng, Hoffmann Patrick, Kufer Peter, Xiao Shouhua, Nahrwold Elisabeth, Lutterbüse Ralf, Wickramasinghe Dineli, Raum Tobias
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention provides a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds a human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising the polynucleotide and a host cell transformed or transfected with the polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of the antibody construct in the treatment of melanoma, and a kit comprising the antibody construct.