Managing isolation requirements of a multi-node workload application

In an approach to manage isolation requirements of a multi-node workload application, a computer determines one or more first isolation levels for each of a plurality of workload nodes. The computer receives performance data for the plurality of workload nodes and analyzes the performance data for statistical trends in the performance data. The computer identifies an adverse trend in the statistical trends of the performance data and identifies a root cause of the adverse trend in the performance data. The computer then identifies one or more second isolation levels required to meet performance targets, the second isolation levels including an adjustment to the first isolation levels for the plurality of workload nodes.