Memory reference metadata for compiler optimization

An apparatus includes a memory and a compiling processor configured to: generate, by at least one of a group consisting of a compiler and a runtime executing on the compiling processor, arguments for executing a compiled kernel, determine, by the at least one of the group executing on the compiling processor, whether a first memory reference to a first memory region and a second memory reference to a second memory region of the arguments refer to a same memory region, generate, by the at least one of the group, metadata associated with the first memory reference and the second memory reference based on the determination, wherein the metadata indicates a relationship between the first memory region and the second memory region. The at least one of the compiler and the runtime may recompile the kernel based on the metadata, and instruct a target processor to execute the recompiled kernel.