Methods and systems for removal of information handling resources in a shared input/output infrastructure

One or more chassis management controllers may be configured to receive a user indication of a user desire to physically remove a modular information handling resource from a chassis, determine whether the modular information handling resource is shared or nonshared with respect to modular information handling systems present in the chassis, determine whether the modular information handling systems associated with the modular information handling resource are powered on, receive at least one response to one query to the user regarding at least one user preference regarding removal of the modular information handling resource, and determine if the information handling resource may be safely removed based at least on: the determinations of whether the information handling system resource is shared or nonshared and whether the modular information handling systems present in the chassis and associated with the modular information handling resource are powered on, and the at least one response.