Terahertz spectroscopy for predicting stability of amorphous drugs

A method for characterizing an amorphous material involves an evaluation of a rate of change with temperature of an interaction of the amorphous material with electromagnetic (EM) radiation. The interaction is at an energy of between 6.6×10−24 J and 6.6×10−21 J, which corresponds to EM radiation in...

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Bibliographische Detailangaben
Hauptverfasser:	Zeitler Jochen Axel, Sibik Juraj
Format:	Patent
Sprache:	eng
Schlagworte:	COLORIMETRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT,POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED,VISIBLE OR ULTRA-VIOLET LIGHT MEASURING PHYSICS RADIATION PYROMETRY TESTING
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Beschreibung
Zusammenfassung:	A method for characterizing an amorphous material involves an evaluation of a rate of change with temperature of an interaction of the amorphous material with electromagnetic (EM) radiation. The interaction is at an energy of between 6.6×10−24 J and 6.6×10−21 J, which corresponds to EM radiation in the terahertz band, between 10 GHz and 10 THz. The rate of change of the interaction is evaluated in a temperature range below a glass transition temperature (Tg) of the amorphous material. The rate of change can then be compared with a predetermined value in order to characterize the amorphorphous material. An apparatus is provided to carry out the method, and the method can produce amorphous materials having desired properties, such as stability against crystallization.