Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4H-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6H-pyrrolo[1,2-α][1,4]benzodiazepine derivatives

Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4H-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6H-pyrrolo[1,2-α][1,4]benzodiazepine derivatives

The present invention concerns novel compounds of Formula (I): wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Meerpoel Lieven, de Wit Kelly, Maes Louis Jules Roger Marie
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention concerns novel compounds of Formula (I): wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.