Percutaneous absorption preparation containing donepezil, and method for preparing same

Provided is a transdermal delivery system (for example, in the form of a patch) having a double-layer structure including a drug-containing matrix layer and an adhesive layer, wherein the drug-containing matrix layer is obtained by completely dissolving donepezil using a certain polymer and then for...

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Bibliographische Detailangaben
Hauptverfasser: Kim Hye-Min, Lee Bong-Yong, Hwang Yong-Youn, Youn Won-No, Kim Hun-Taek, Park Yeo-Jin, Im Jong-Seob, Oh Joon-Gyo
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Provided is a transdermal delivery system (for example, in the form of a patch) having a double-layer structure including a drug-containing matrix layer and an adhesive layer, wherein the drug-containing matrix layer is obtained by completely dissolving donepezil using a certain polymer and then formulating along with an adhesive; and a process for preparing the same. The transdermal delivery system according to the present invention does not show any crystallization of donepezil in the formulation, can release donepezil at a uniform rate for a long time, and can inhibit the release dumping phenomenon that occurs in a transdermal delivery system having a single-layer structure.