Triazolyl derivatives as Syk inhibitors

Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

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Bibliographische Detailangaben
Hauptverfasser:	Otte Ryan D, Ellis John Michael, O'Boyle Brendan, Kattar Solomon D, Wu Lingyun, Reutershan Michael H, Altman Michael D, Beaulieu Christian, Vitharana Dilrukshi, Donofrio Anthony, Northrup Alan B, Ducharme Yves, Machacek Michelle R, Christopher Matthew, Childers Kaleen Konrad, Cash Brandon, Romeo Eric T, Zhang Li, Guay Daniel, Grimm Jonathan, Spencer Kerrie, Haidle Andrew M, Zhang Peng
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.