Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors

Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, s...

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Bibliographische Detailangaben
Hauptverfasser: Crooks Peter, Dwoskin Linda P, Sumithran Sangeetha, Zheng Guangrong
Format: Patent
Sprache:eng
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Zusammenfassung:Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.