Opsin-binding ligands, compositions and methods of use

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic is visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins an...

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Bibliographische Detailangaben
Hauptverfasser: Greenwood Jeremy R, Cote Jamie B, Larosa Gregory J, Frye Leah L, Quach Tan, Berman Judd, Garvey David S
Format: Patent
Sprache:eng
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Zusammenfassung:Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic is visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.