6-heteroaryloxy- or 6-aryloxy-quinoline-2-carboxamides and method of use

6-heteroaryloxy- or 6-aryloxy-quinoline-2-carboxamides and method of use

and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for maki...

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Bibliographische Detailangaben
Hauptverfasser: Peltier Hillary, Bogdan Andrew, Koenig John R, Nelson Derek W, Patel Meena V, DeGoey David A, Kort Michael E, Jinkerson Tammie K, Liu Bo, Matulenko Mark A, Scanio Marc J, Cowart Marlon D, Wakefield Brian D
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.