Low hygroscopic aripiprazole drug substance and processes for the preparation thereof

The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous aripiprazole crystals is stored for an extended period.

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Bibliographische Detailangaben
Hauptverfasser:	YAMADA SHOHEI, TAKAHASHI MASANORI, TOMINAGA MICHIAKI, AOKI SATOSHI, FUJIMOTO KIYOSHI, SHINHAMA KOICHI, NISHIOKA YOSHIHIRO, NAKAGAWA TOMONORI, KAWASAKI JUNICHI, TOMIKAWA KENJI, ISHIGAMI MAKOTO, ABE KAORU, TANIGUCHI YOUICHI, KOBAYASHI NORIYUKI, YABUUCHI TSUYOSHI, BANDO TAKUJI, UTSUMI NAOTO, FUJIMURA TSUTOMU, OOI YOSHIHIRO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING
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Beschreibung
Zusammenfassung:	The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous aripiprazole crystals is stored for an extended period.