Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors

Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors

The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BOEZIO CHRISTIANE, GAO HUA, DIMAURO ERIN F, LA DANIEL, WEISS MATTHEW, BOEZIO ALESSANDRO, COPELAND KATRINA WOODIN, CHAKKA NAGASREE, PETERSON EMILY ANNE, COATS JAMES R, BREGMAN HOWARD, NGUYEN HANH NHO, MARX ISAAC E, DINEEN THOMAS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.