Identifying individual sub-regions of the cardiovascular system for calcium scoring

A method includes identifying a plurality of different anatomical sub-regions of the cardiovascular system of a subject in image data of the subject based on a subject specific cardiovascular anatomical model, wherein the plurality of different regions corresponds to regions where calcifications occur, searching for and identifying calcifications in the sub-regions based on voxel grey value intensity values of the image data, and generating a signal indicative of one or more regions of voxels of the image data respectively corresponding to sub-regions including identified calcifications. A computing system (118) includes a processor that automatically determines a plurality of different groups of voxels of image data of a subject, wherein each group of voxels corresponds to a different sub-region of the cardiovascular system of the subject and each group of voxels corresponds to a region that includes a calcification identified in the image data.