Process for the preparation of 5-fluoro-1H-pyrazoles

Process for the preparation of 5-fluoro-1H-pyrazoles

A new process for the preparation of 5-fluoro-1H-pyrazoles of the general formula (I) is described, resulting from the reaction of an olefin of the general formula (II) with hydrazines of the formula (III) R1-NH-NH2  (III), wherein R1 is selected from C1-C6 alkyl, C5-C10 aryl; R2 is a trihalomethyl...

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Hauptverfasser: TIMOSHENKO VADIM MIKHAILOVICH, SHERMOLOVICH YURIY GRIGOVERIEVICH, PAZENOK SERGII, LUI NORBERT, KAMINSKAYA ELENA IVANOVNA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A new process for the preparation of 5-fluoro-1H-pyrazoles of the general formula (I) is described, resulting from the reaction of an olefin of the general formula (II) with hydrazines of the formula (III) R1-NH-NH2  (III), wherein R1 is selected from C1-C6 alkyl, C5-C10 aryl; R2 is a trihalomethyl moiety with at least one fluorine atom; and R3 is selected from C1-C5 haloalkyl, CF3, C2F5, C3F7, CF2CF2Cl, CFClCF3, in the presence of water and a base.