Methylene linked quinolinyl modulators of RORγt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthri...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	KREUTTER KEVIN D, VENKATESAN HARIHARAN, LEONARD KRISTI A, NISHIMURA RACHEL, BARBAY KENT, WOODS CRAIG R, EDWARDS JAMES P, XUE XIAOHUA, FOURIE ANNE, CUMMINGS MAXWELL D, URBANSKI MAUD, MAHAROOF UMAR, JONES WILLIAM MOORE, WANG AIHUA, KUMMER DAVID A, WOLIN RONALD L, GOLDBERG STEVEN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.