N,N1 substituted piperazines having combined antiaggregant, anticoagulant and vasodilatory activity, and method for producing same

The invention relates to derivatives of N,N′-substituted piperazines of the general formula (I): where R1 and R2 denote linear or branched (C1-C4)alkyl, linear or branched (C1-C4)alkoxy, CH3C( O)O or halogen; n=1-5; m=0-3; Z denotes CH2, C O or SO2; X denotes C( NH)NH2, C( NH)NHC( NH)NH2 or CH2(CHR3)pCH2SO3H, where R3 denotes H, OH, CH3C( O)O or HOSO2O and p=0-1; and G denotes low-molecular-weight organic or mineral acid, sodium, potassium or ammonium cations, or water. Said derivatives have antiaggregant, anticoagulant and vasodilatory properties. The invention further relates to a method for producing said derivatives by reacting N-substituted piperazines either with carboxamide amidating agents or salts thereof, or with haloalkyl sulfonic acids or salts thereof in organic solvents or in water in the presence of bases. The compounds may be used for the prophylaxis and treatment of disorders of the hemostatic system.