Reversing intestinal inflammation by inhibiting retinoic acid metabolism

An agent that increases local concentration of retinoic acid (RA) in the intestine through modifying enzymatic pathways involved in RA metabolism is administered in a dose effective to inhibit or reverse production of inflammatory mediators by intestinal dendritic cells and thereby reduce intestinal...

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Hauptverfasser: PENNY HWEIXIAN LEONG, ENGLEMAN EDGAR G
Format: Patent
Sprache:eng
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Zusammenfassung:An agent that increases local concentration of retinoic acid (RA) in the intestine through modifying enzymatic pathways involved in RA metabolism is administered in a dose effective to inhibit or reverse production of inflammatory mediators by intestinal dendritic cells and thereby reduce intestinal inflammation and tumor growth associated with intestinal inflammation.