Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C

Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C

The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZORN NICOLAS, LI PENG, LIU HONG, PENG XUANJIA, GUO TAO, PALANI ANANDAN, HE SHUWEN, XIAO DONG, MARCANTONIO KAREN, NARGUND RAVI, BROCKUNIER LINDA L, DAI XING
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.