System-level adaptive minimization of interference in multi-function radios

A method and apparatus that mitigates self-interference among various receivers and transmitters in a multifunction radio includes a transmitter operating in a first frequency band and a receiver operating in a second frequency band, different from the first frequency band. Jamming factors for multiple frequency channels in the first frequency band are calculated based on possible interference with the second frequency band by artifacts of the respective frequency channels. The frequency channel having the smallest jamming factor is selected as the frequency to be used by the transmitter.