Drug condensation aerosols and kits

The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rap...

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Bibliographische Detailangaben
Hauptverfasser: LU AMY T, MYERS DANIEL J, RABINOWITZ JOSHUA D, HALE RON L, HODGES CRAIG C, LLOYD PETER M, WENSLEY MARTIN J, ZAFFARONI ALEJANDRO C, MCKINNEY JEFFREY A
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided, wherein the device, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Methods for use are also disclosed.