A-beta binding polypeptides

The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypep...

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Bibliographische Detailangaben
Hauptverfasser:	VERCAMMEN JO, ZIMMERMAN KATHARINA, DORNER-CIOSSEK CORNELIA, LAEREMANS TOON, LENTER MARTIN, MERCHIERS PASCAL GERARD, HOERER STEFAN, KUSSMAUL LOTHAR, BESTE GERALD, PARK JOHN E
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.