Communications over multiple protocol interfaces in a computing environment

According to one aspect of the present disclosure, a method and technique for communications over multiple protocol interfaces in a computing environment is disclosed. The method includes: identifying a network interface for egress data packet communications; responsive to the identified network interface differing from a data packet fragmentation technique desired for the data packet communications, deriving fragmentation data according to the desired data packet fragmentation technique; generating an application layer header for the data packet communications; storing values of the fragmentation data in select fields of the application layer header; fragmenting the data packet communications according to the desired data packet fragmentation protocol; and transmitting the data packet communications including the application layer header over the identified network interface.